Hierarchical Structure of Protein Protein Interaction Networks

Prediction of Protein Sub-Mitochondria Locations Using Protein Interaction Networks

Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...

Hierarchical Structure of the Protein-protein Interaction Networks

1 Department of Biological Science and Technology, Taichung Healthcare and Management University, No.500, Lioufeng Road, Wufeng Shiang,Taichung, Taiwan 413 2 The Affiliated Senior High School of National Taiwan Normal University, Taipei, Taiwan 3 Department of Computer Science and Information Engineering, National Huwei University of Science and Technology, 64, Wen-Hwa Road, Hu-Wei, Yun-Lin, Ta...

Study of PKA binding sites in cAMP-signaling pathway using structural protein-protein interaction networks

Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...

Construction and Analysis of Tissue-Specific Protein-Protein Interaction Networks in Humans

We have studied the changes in protein-protein interaction network of 38 different tissues of the human body. 123 gene expression samples from these tissues were used to construct human protein-protein interaction network. This network is then pruned using the gene expression samples of each tissue to construct different protein-protein interaction networks corresponding to different studied ti...

Hierarchical and Topological Study of the protein-protein Interaction Networks